0000001 - Document - Cover Page link:presentationLink link:calculationLink link:definitionLink 0000002 - Document - Audit Information link:presentationLink link:calculationLink link:definitionLink 0000003 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 0000004 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 0000005 - Statement - Consolidated Statements of Income (Loss) and Comprehensive Income (Loss) link:presentationLink link:calculationLink link:definitionLink 0000006 - Statement - Consolidated Statements of Changes in Stockholders’ Equity link:presentationLink link:calculationLink link:definitionLink 0000007 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 0000008 - Disclosure - Nature of Operations link:presentationLink link:calculationLink link:definitionLink 0000009 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 0000010 - Disclosure - Recent Accounting Pronouncements link:presentationLink link:calculationLink link:definitionLink 0000011 - Disclosure - Net Income (Loss) per Share link:presentationLink link:calculationLink link:definitionLink 0000012 - Disclosure - Investments link:presentationLink link:calculationLink link:definitionLink 0000013 - Disclosure - IPR&D and Goodwill link:presentationLink link:calculationLink link:definitionLink 0000014 - Disclosure - Property and Equipment link:presentationLink link:calculationLink link:definitionLink 0000015 - Disclosure - Intangible Assets link:presentationLink link:calculationLink link:definitionLink 0000016 - Disclosure - Liabilities link:presentationLink link:calculationLink link:definitionLink 0000017 - Disclosure - Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 0000018 - Disclosure - Government Grants and Credits link:presentationLink link:calculationLink link:definitionLink 0000019 - Disclosure - Research, Collaboration and Licensing Agreements link:presentationLink link:calculationLink link:definitionLink 0000020 - Disclosure - Other Income, net link:presentationLink link:calculationLink link:definitionLink 0000021 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 0000022 - Disclosure - Leases link:presentationLink link:calculationLink link:definitionLink 0000023 - Disclosure - Financial Instruments link:presentationLink link:calculationLink link:definitionLink 0000024 - Disclosure - Commitment and Contingencies link:presentationLink link:calculationLink link:definitionLink 0000025 - Disclosure - Restructuring link:presentationLink link:calculationLink link:definitionLink 0000026 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 0000027 - Disclosure - Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 0000028 - Disclosure - Net Income (Loss) per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 0000029 - Disclosure - IPR&D and Goodwill (Tables) link:presentationLink link:calculationLink link:definitionLink 0000030 - Disclosure - Property and Equipment (Tables) link:presentationLink link:calculationLink link:definitionLink 0000031 - Disclosure - Intangible Assets (Tables) link:presentationLink link:calculationLink link:definitionLink 0000032 - Disclosure - Liabilities (Tables) link:presentationLink link:calculationLink link:definitionLink 0000033 - Disclosure - Stockholders' Equity (Tables) link:presentationLink link:calculationLink link:definitionLink 0000034 - Disclosure - Government Grants and Credits (Tables) link:presentationLink link:calculationLink link:definitionLink 0000035 - Disclosure - Research, Collaboration and Licensing Agreements (Tables) link:presentationLink link:calculationLink link:definitionLink 0000036 - Disclosure - Other Income, net (Tables) link:presentationLink link:calculationLink link:definitionLink 0000037 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 0000038 - Disclosure - Leases (Tables) link:presentationLink link:calculationLink link:definitionLink 0000039 - Disclosure - Financial Instruments (Tables) link:presentationLink link:calculationLink link:definitionLink 0000040 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 0000041 - Disclosure - Summary of Significant Accounting Policies - Summary of Estimated Useful Lives (Detail) link:presentationLink link:calculationLink link:definitionLink 0000042 - Disclosure - Summary of Significant Accounting Policies - Summary of Definite-lived Intangible Assets, Estimated Useful Lives (Details) link:presentationLink link:calculationLink link:definitionLink 0000043 - Disclosure - Net Income (Loss) per Share - Summary of Calculation of Diluted Loss Per Share (Detail) link:presentationLink link:calculationLink link:definitionLink 0000044 - Disclosure - Investments (Detail) link:presentationLink link:calculationLink link:definitionLink 0000045 - Disclosure - IPR&D and Goodwill - Summary of Carrying Value of IPR&D, Net of Impairment (Detail) link:presentationLink link:calculationLink link:definitionLink 0000046 - Disclosure - IPR&D and Goodwill - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 0000047 - Disclosure - Property and Equipment - Components of Property and Equipment (Detail) link:presentationLink link:calculationLink link:definitionLink 0000048 - Disclosure - Property and Equipment - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 0000049 - Disclosure - Intangible Assets - Schedule of Intangible Assets (Detail) link:presentationLink link:calculationLink link:definitionLink 0000050 - Disclosure - Intangible Assets - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 0000051 - Disclosure - Intangible Assets - Schedule of Future Amortization Expense (Details) link:presentationLink link:calculationLink link:definitionLink 0000052 - Disclosure - Liabilities - Schedule of Accounts Payable and Accrued Expenses (Detail) link:presentationLink link:calculationLink link:definitionLink 0000053 - Disclosure - Liabilities - Schedule of Other Long-term Liabilities (Detail) link:presentationLink link:calculationLink link:definitionLink 0000054 - Disclosure - Stockholders' Equity - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 0000055 - Disclosure - Stockholders' Equity - Summary of RSUs Outstanding (Details) link:presentationLink link:calculationLink link:definitionLink 0000056 - Disclosure - Stockholders' Equity - Summary of Stock Options Granted (Detail) link:presentationLink link:calculationLink link:definitionLink 0000057 - Disclosure - Stockholders' Equity - Schedule of Non-Vested Stock Option Activity (Detail) link:presentationLink link:calculationLink link:definitionLink 0000058 - Disclosure - Stockholders' Equity - Schedule of Stock-based Compensation Expense for Equity Classified Instruments (Detail) link:presentationLink link:calculationLink link:definitionLink 0000059 - Disclosure - Stockholders' Equity - Schedule of Estimated Fair Value of Stock Options Assumptions (Detail) link:presentationLink link:calculationLink link:definitionLink 0000060 - Disclosure - Government Grants and Credits - Component of Government Grants and Credits (Detail) link:presentationLink link:calculationLink link:definitionLink 0000061 - Disclosure - Government Grants and Credits - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 0000062 - Disclosure - Research, Collaboration and Licensing Agreements - Schedule Of Collaborative Arrangements and Noncollaborative Arrangement Transactions (Detail) link:presentationLink link:calculationLink link:definitionLink 0000063 - Disclosure - Research, Collaboration and Licensing Agreements - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 0000064 - Disclosure - Other Income, net -Schedule Of Other Non operating Income Expense (Details) link:presentationLink link:calculationLink link:definitionLink 0000065 - Disclosure - Income Taxes - Schedule of Income Tax Expense (Recovery) (Detail) link:presentationLink link:calculationLink link:definitionLink 0000066 - Disclosure - Income Taxes - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 0000067 - Disclosure - Income Taxes - Schedule of Effective Income Tax Rate Reconciliation (Detail) link:presentationLink link:calculationLink link:definitionLink 0000068 - Disclosure - Income Taxes - Summary of Significant Components of Deferred Income Tax Assets and Liabilities (Detail) link:presentationLink link:calculationLink link:definitionLink 0000068 - Disclosure - Income Taxes - Summary of Significant Components of Deferred Income Tax Assets and Liabilities (Detail) link:presentationLink link:calculationLink link:definitionLink 0000069 - Disclosure - Income Taxes - Summary of Expiry Details of Investment Tax Credits, Non-Capital Losses and Net Operating Losses for Income Tax Purposes (Detail) link:presentationLink link:calculationLink link:definitionLink 0000070 - Disclosure - Income Taxes - Schedule of Reconciliation of Beginning and Ending Amounts of Unrecognized Tax Benefits (Detail) link:presentationLink link:calculationLink link:definitionLink 0000071 - Disclosure - Leases - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 0000072 - Disclosure - Leases - Schedule of Balance Sheet Classification of Lease Liabilities (Detail) link:presentationLink link:calculationLink link:definitionLink 0000073 - Disclosure - Leases - Schedule of Future Minimum Lease Payment Operating Lease Liabilities (Detail) link:presentationLink link:calculationLink link:definitionLink 0000073 - Disclosure - Leases - Schedule of Future Minimum Lease Payment Operating Lease Liabilities (Detail) link:presentationLink link:calculationLink link:definitionLink 0000074 - Disclosure - Financial Instruments - Schedule of Financial Liabilities Measured at Fair Value on a Recurring Basis (Detail) link:presentationLink link:calculationLink link:definitionLink 0000075 - Disclosure - Financial Instruments - Summary of Changes in Fair Value of the Company's Liability for Contingent Consideration (Detail) link:presentationLink link:calculationLink link:definitionLink 0000076 - Disclosure - Financial Instruments - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 0000077 - Disclosure - Commitment and Contingencies (Details) link:presentationLink link:calculationLink link:definitionLink 0000078 - Disclosure - Restructuring (Details) link:presentationLink link:calculationLink link:definitionLink